Zabiyaka L. Peripheral blood circulation and tissue oxygen provision in elderly patients with hypertensive disease and their changes under the influence of antihypertensive therapy.

The clinico-instrumental complex (24 - hour arterial blood pressure monitoring, tetrapolar chest rheography, laser doppler flowmetry, television bionucroscopy and microphotography of the finger nail bed of the left hand, bulbar bionucroscopy, polarography) was used in 121 elderly and middle-aged patients with hypertensive disease to study the age-related changes in microcirculation and tissue oxygen provision and their changes under the influence of enalapril, amiodipin and atenolol. It was established that with age the deterioration of capillary blood flow characterized by a decrease in the number of open capillaries, the slowing down of skin blood flow velocity, the decrease in diameter of capillary arterial parts occurred and also the lengthening and tortuosity of capillaries were seen. The comparative analysis of efficacy of enalapril, amiodipin and atenolol with assessment of their effects on haemodynamics, microcirculadon and oxygen provision in elderly and middle-aged patients with hypertensivedisease showed that alongside with normalization of arterial blood pressure occurred also the improvement in microcirculation evidenced by an increase in skin blood flow volume velocity, the amelioration of character and velocity of capillary blood flow. With it the most significant positive changes in the system of microcirculation, and tissue oxygen provision were observed in patients with hypertensive disease treated with amiodipin. Somewhat less pronounced they were in those treated with enalapril. Still less pronounced they were in patients who were given atenolol.