Gorshunska M. Oxidative stress parameters and lipid profile in Type 2 diabetic women.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0402U002071

Thesis Registration Form

0402U002071.pdf

Applicant for

Specialization

  • 14.01.14 - Ендокринологія

21-06-2002

Specialized Academic Board

Д 26.558.01

STATE INSTITUTE "V.P. KOMISSARENKO INSTITUTE OF ENDOCRINOLOGY AND METABOLISM OF THE NATIONAL ACADEMY OF MEDICAL SCIENCE OF UKRAINE"

Essay

The dissertation is devoted to studing the metabolic disturbances in Type 2 diabetic women (DW) with different menopausal status and vascular complication degree. The work is aimed on determining the dynamics of oxidative stress and lipid profile parameters in DW under conventional therapy and combined with antioxidants. By clinical, biochemical, radioimmunological methods using spectrophotometer, gammacounter it was revealed in DW with insulin resistance (a) the dominant significance of dyslipidemia vs hyperglycemia for oxidative stress genesis, (b) the pathogenic role of the last in lost of оestrogens favourable impact on metabolic risk factors for atherosclerosis (dyslipidemia, lipid oxidation) and (c) vitamins E+C therapeutical efficacy. There were determined pathogenic mechanisms of metabolic risk factors for angiopathies development in Type 2 DW. The results may be used for DW treatment and in lecture courses at medical educational infatuations.

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Files

aref.doc

dis (1).doc

dis(r3).doc

dis(r4).doc

dis(r6-7).doc

lit.doc

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