PIL'O S. Syntheses of new azoles derivatives on the basis of 2-acylamino-3,3-dichloroacrylonitriles and their analogues

Convenient methods for preparation of 1,2- and 1,3-azoles derivatives based on available electrofilic reagents: 2-acylamino-3,3-dichloroacrylonitriles and their analogues were investigated. It was shown that the titled reagents peculiarly interacted with various S- and N-nucleophiles to give a great number of new 5-mercapto-1,3-oxazole, 5-mercapto-1,3-thiazole, 5-amino-2-formyl-1,3-oxazole, 5-hydrazino-l ,3-oxazole, 5-phenylazo-1,3-oxazole derivatives as well as some substituted pyrazoles and 1,3,4-oxadiazoles. These latter were obtained as a result of a new ring transformation which took place on heating acyi derivatives of substituted 5-hydrazino-1,3-oxazoles. All of the mentioned azoles derivatives contained biological important groups and, for this reason, were perspective for searching bioregulators with diverse actions.