Spivak S. Relevance of proliferative, adhesive, activate properties of cancer cells and lymphocytes for their interaction in dynamics of tumor growth (experimental - clinical study)

The dissertation is aimed to study the interaction lymphocytes and tumor cells in dynamics of malignant process in mice with experimental tumors and patients with soft tissue sarcoma and the definition of importance expression of activations, proliferations and adhesions markers of lymphocytes and tumor cells for their interaction. The significant antitumor action of lymphocytes in mice with transplanted МX-rhabdomyosarcoma is combined with a high level expression of adhesive molecules CD54, interleukin-2 receptor and IgM on lymphocytes and CD54 on tumor cells. Antitumor action of lymphocytes at rhabdomyosarcoma induced methylcholantren is combined with expression of antigen's proliferation and interleukin-2 receptor on lymphocytes. It was shown, that significant antitumor action of lymphocytes of the patients with soft tissue sarcoma is combined with expression of interleukin-2 receptor, adhesive molecules CD11b on lymphocytes and expression CD54 on tumor cells