Vitko Y. Volume-regulated chloride channels in human prostate carcinoma cell line: the effects of calcium-chelating agents, pH and proteases.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0403U000851

Thesis Registration Form

0403U000851.pdf

Applicant for

Specialization

  • 03.00.02 - Біофізика

11-03-2003

Specialized Academic Board

Д 26.198.01

Bogomoletz Institute of Physiology National of science of Ukraine

Essay

It was investigated the volume-activated chloride current in human prostate cancer epithelial cells. It was reported that calcium-chelating agents produce directly inhibition of current. Extracellular pH and intracellular trypsin effected on amplitude, kinetics and volume-sensitivity of volume-activated chloride current. We conclude that volume-regulated chloride channel possess structural domains that underlying pH-dependence, permeability, volume-sensitivity and inactivation of volume-regulated chloride channels.

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Files

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ДИСЕРТ~1.DOC

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