Klymchenko A. Fluorescence probes based on 3-hydrohychromone: synthesis, spectral and sensing properties, and examinations in model biological systems.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0403U001341

Thesis Registration Form

0403U001341.pdf

Applicant for

Specialization

  • 02.00.10 - Біоорганічна хімія

15-04-2003

Specialized Academic Board

Д26.001.25

Essay

Based on 3-hydroxychromone (3HC) a new generation of two-band fluorescent probes, operating by excited state intramolecular proton transfer (ESIPT) principle, was developed. Тhe classical method of synthesis of 3НС was improved. New 3HC derivatives were synthesized that show improved fluorescence properties. The sensor properties of new 3HC derivatives were studied in solvents and reversed micelles. New 3HC biomembrane probes were developed exhibiting in the bilayer certain localization. Dependent on the latter they demonstrate different sensitivity to the surface potential and properties of the hydrophobic region of the membrane.

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Files

Disser-Glava_1-3.doc

Glava_4.doc

Glava_5-7.doc

arf.doc

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