Кiselyk I. L-arginine and nitric oxide bonds for the patients by virus hepatitis's. Theoretical and practical aspects of their researches.

In a thesis the results of clinical-biochemical researches 206 patients by acute and chronic virus hepatitis's of different aetiology are stated. It has been established, that for the patients with acute and chronic virus hepatitis's the contents of L-arginine and nitrous bonds considerably rise (NO2, NO2- and NO3-) in blood. In acute viral hepatitis's the high level of L-arginine in the patients serums was observed. In good-quality streaming virus hepatitis's, in particular hepatitis A, its parameters were quickly normalised. In acute hepatitis B more appreciable was observed, than at hepatitis А, increasing levels of L-arginine in the beginning of the illness and their deflection from norm at an from the hospital. In acute hepatitis С the level of L-arginine was a little bit above than that seeing hepatitis В and practically did not vary during all acute season. It hassle been reported that the level of NO2- in an inte-gral blood of the patients on acute hepatitis's and, in and with at hospitalisation ex-ceeded parameters of the healthy persons in 2-3 times, whereas in serums this pa-rameter exceeded norm in 5-6,5 times. Contents of NO3- in an integral blood of the patients on acute hepatitis's and in and with at the moment of hospitalisation ex-ceeded parameters of control group in 2,5-3 times. At inspection of the patients chronic hepatitis В, hepatitis С and hepatitis B+C fixed, that all parameters (L-arginine and the nitrous bonds) practically for all inspected exceeded norm, and the treatment in the hospital did not have any influence on the changes of their values. The obtained results allow to verity, that the levels both changes of L-arginine and nitric oxide bonds in acute viral hepatitis's depend on the aetiology of the illness and, in a smaller measure, from the severity and duration of their course.