Vinichtnko L. Pathogenetic substantiation of treatment of patients gastroesophageal reflux illness depending on клинико-morphological current

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0403U003262

Applicant for

Specialization

  • 14.01.02 - Внутрішні хвороби

30-09-2003

Specialized Academic Board

К 29.600.01

Essay

124 patients of gastroesophageal reflux disease were investigated. The dissertation is devoted to the complex studying of clinical and morphological course of gastroesophageal reflux disease in dependence of gender, age, terms of disease, presence of hiatus hernia, Helicobacter pylori colonization. Helicobacter pylori colonization and effect of Helicobacter pylori eradication according to the severity and pattern of gastritis were examined. Reflux symptoms may actually be improved by eradication in patients with predominantly antral gastritis. The risks and benefits of Helicobacter pylori eradication for reflux esophagitis healing and symptoms improve are less clearly defined for patients with pangastritis and especially with predominantly corpus gastritis. Hiatus hernia and failure of initial proton pomp inhibitor treatment during 8 weeks are risk factor for impaired gastroesophageal competence and is associated with the risk for development of reflux esophagitis relapses following Helicobacter pylorieradication. The main results have been introduced into the clinical practice. The using area is a medicine.

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