Timoshenko S. Pathologicoanatomical changes of the cerebral microvessels in the dynamic of the post-reanimation encephalopathy.

3. Object of the studi: arterioles, capillaries, venulae of cortex and cerebral white substance. Purpose of the studi: To establish the objective laws of morphogenesis of destructive , adaptive and reparative changes Of cerebral microvessels in prognostically different postreanimative encephalopathies for using in pathologicoanatomic diagnostics. Methods of the studi: Light microscopy, electronic microscopy, historadioautography, morfometry with statistic analysis of quantitative findings, brain blood flow was determined by the method of calculation. Practical significance of the obtained results: Areactive desintegration of non-functioning capillaries, macrophageal desintegration of caval venulae, caval arteriole obliteration are proved to develop in blood-flow non-resuming areas during the first week. Microscopic manifestations of reparative angiogenesis which in the most evidently revealed on the 7-14th day after clinical death are described. Then angiogenesis intensity reducesand doesn’t stop until the 130th day after clinical death. Adaptive circular stenosis of arterioles, recalibration and formation of many truncal arterioles and venule are revealed on the 5-7th till 130th day after clinical death. Non-resuming of cerebral hemomicrocirculation instantly after clinical death and its reccurens in distant period after clinical death are characteriotics of postreanimative disease. Novelty of the obtained results: The interconnection between a microcirculatory disorder type and a pathologicoanatomic form and spreading of brain postreanimative necroses is concretized. It is established that during 130 days after clinical days the processes of reendothelization are observed in functioning cerebral microvessels. It is proved that reparative angiogenesis in all parts of brain microcirculator bed after survived clinical death occurs by the way of formation of endothelial proliferates, the buds of growth and vessels branches; the reparative angiogenesis starts later in cerebral postreanimative necroses and is pronounced less intensively than in brain infaretion caused by cerebrovascular diseases. In prognostically favourable postreanimative encephalopathy only transitory quantitative reducing of functional capillaries is recorded in cats with disintegration of separate dehematized capillaries is timely compensated by reparative capillarogenesis, therefore the change in total quantity of cerebral microvessels doesn’t occur meanwhile the belated and excessive capillarogenesis takes place in coma dead with postreanimative mozaic-fire selective-neurone affection of CNS . Degree of introduction: The results of the investigation are implemented into practical work of the departments of Zaporozhye Regional Pathologicoanatomic Bureau and used in training at the Chair of Pathological Anatomy and the Chair of Nervous Diseases of Zaporozhye State Medical University as well as at the Chair of Anaesthesiology and Reanimation of Zaporozhye Institute for Advanced Doctor’s Study. Area of application: medicine, Pathological Anatomy.