Kysil O. Structure peculiarities of plasma and mitochondria membranes of rat small intestine enterocytes at action of ionizing radiation and cadmium.

The thesis is devoted to the comparative investigation of one-time (1,0 Gy) and chronic (in integral absorbed doses 0,3 Gy, 0,6 Gy and 1,0 Gy, dose rate 0,72cGy/day) ionizing radiation, separately or together with low doses of cadmium, on the physicochemical properties of plasma, namely apical membrane (АM), and inner mitochondria membrane (MM) of small intestine enterocytes. The expressed modification of physical properties of AM surface layer as against MM and breaking of lipid component of these two membranes are shown under ionizing radiation and cadmium chronic activity. MM protein - lipid complex reconstruction is observed under these research conditions. АМ and MM structural state changes and the intramolecular dynamics of these membrane protein molecules are revealed under different conditions of research. Content versatile changes of cholesterol and phospholipids, rising of lysoforme level, redistribution in accumulation of lipid peroxidation products are exposed for АМ and MM at one-time andchronic activity of ionizing radiation and cadmium. Breaking of small intestine enterocyte АМ and MM transmembrane Са2+ transfer is shown at activity of investigated factors. With the use of factor analysis method the revealed different pathways of embodying of breaking of enterocyte AM and MM structure, induced with one-time or chronic ionizing radiation activity, separately and combined with cadmium, are confirmed.