Research subjects: flora of the Lugansk region. Research objectives: determination of the modern state, conformities to the law of forming, tendencies of future development and ways of renewal was the purpose of work and saving of flora of vascular plants of the Lugansk region. Methods: floristically, comparative ecology-geography- anatomy-morphological, taxonomical, arealogical, sozological. Theoretical and practical results: the complex taking of inventory of flora is first conducted, including the natural and cultural plants, all territory of the Lugansk region; its specific composition (1804 kinds) is certain and an annotated list of plants is made; The results of researches were used for preparation of botanical and ecological works, monitoring and examination of the common state of environment, development and ground of conception of ecological network of the Lugansk region, to preparation of decisions of regional and district soviets and administrations on the questions of the use, renewal andguard of vegetable resources, exposition of laboratory-lecture courses and the field practical worker on botanical disciplines in middle (schools, lyceums, koledgi) and higher (pedagogical, agrarian, medical, East-Ukrainian universities) educational establishments of region. Novelty of introduced: the comprehensive and deep analysis of flora and its structure is presented; generalization data of tafoflorical region; continuity of development of flora of long period is grounded and conformities to the law of genesis of flora of region from factors which determine its forming and development are exposed; the completest description of rare and vanishing types of plants is presented, state of their populations, rare florofond is analysed, the ways of renewal and guard of these plants are offered; complete economic description of florofond is presented and the ways of his use are certain; the credible prognosis of further development of flora and separate kinds under influencing of natural and anthropogenic factors is made. Implementation degree: the results of floristically developments are passed to Management of ecology and natural resources, regional and district administrations, scientific and educational establishments. Effectiveness: developments provided the optimum use of flora and ground of ecological network of region, high level of teaching of botanical distsipiіn in middle and higher educational establishments. Sphere, sector of implementation: botany, ecology, planting of greenery, forest and rural economy, preparation of specialists.