Tkachyov R. Synthesis of pyridine-2-thioles by nucleophilic vinylic substitution reaction, their structure and properties

Investigation objects: 4-unsubstituted 2-sulfanylpyridines and heterocyclic systems on its base. Purpose: preparing of methods of synthesis of 4-unsubstituted 2-sulfanyl-3-ethoxycarbonyl(carbamoyl, arylcarbamoyl, cyano)pyridines by nucleophilic vinylic substitution reaction, study of its structure and possible transformation ways. Methods: X-ray structural analysis, 1H NMR, IR and mass-spectroscopy, elementary analysis. Borders of the nucleophilic vinylic substitution reaction's use for obtaining of early unknown 4-unsubstituted pyridines with mercaptofunction have been estimated. At first isolated products of nucleophilic vinylic substitution, that formed as result of interaction thiocarbamoylcontaining CH-acids with 3-ethoxyacrylic acid's derivatives and way their purposeful transformation to ethyl-4-(4-phenyl-1,3-thiazol-2-yl)-2,4-dicyanobut-2-enoates was found. Compete process is the formation of pyrimidine structure. Degree of application: using at studying process at teaching subjects of specialization far 4-5 years students on the chemistry and biochemistry chair of Taras Shevchenko LNPU.