Yakshibaeva Y. The role of endogenous lectins and carbohydrates in aggregation, adhesion, and migration of malignant cells

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0404U002197

Thesis Registration Form

0404U002197.pdf

Applicant for

Specialization

  • 14.01.07 - Онкологія

12-05-2004

Specialized Academic Board

Д 26.155.01

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine

Essay

It has been shown that spontaneous metastasizing carcinoma 3LL and melanoma B16 have significant differences from nonmetastatic MCA sarcoma both in expression of endogenous lectins and in reactivity of cell aggregation upon effect by exogenous carbohydrate. Influence on carcinoma 3LL and melanoma B16 aggregation by different carbohydrates was unilateral. All used carbohydrates inhibited aggregation of metastatic cells. On the contrary, influence on MCA sarcoma aggregation by carbohydrates varied from stimulation to the absence of any effect. All used carbohydrates inhibited migration of metastatic cells. Severity of the inhibition of carcinoma 3LL and melanoma B16 migration by the majority of carbohydrates was unalterable upon coculturing with spleenocytes from tumor-bearing mice

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Files

01 Title.doc

02 Contents.doc

03 Introduction.doc

04 Chapter 1.doc

05 Chapter 2.doc

06 Chapter 3.doc

07 Chapter 4.doc

08 Chapter 5.doc

09 Analysis.doc

10 Conclusions.doc

11 References.doc

Avtoreferat.doc

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