Ananyeva M. Correction of disturbance of the immunity and purine exchange at the system lupus erynhematosus (clinico-experimental investigations).

Dissertation devoted to the study of as character of the correlation between the disturbances of immunity and purine exchange for the quest new ways for their mutual correction to the patients of SLE. In experiments with 150 mice to the line MRL/lpr, 70 ordinary rats, and 70 rats to the line Wister. With model of system autoimmune diseases on mice and rats importants disturbances of immunity and purine exchange strongly connected between the reselves are detected. In 70 experimental patients for SLE the essential impairments of cellutar and humoral immunity with defeat T - system immunity and expressive reactions autoimmune of cellutar and humoral types were manifested. Also among them recording UA advancement hyperproduction uric acid, activity KO, disturbance correlations nucleotide cyclices are registrated. Disturbance of immunity and purine exchange strongly connected between thereselves are.In experiments for MRL/lpr mice and rats Wister line nessary and effectivity to complex therapy action of autoimmune diseases of KO inhibitors was used.SLE effectivity utilization of complex terapy the KO inhibitors was demonstrate.