Hayduchok I. Immunopathological syndromes in patients with systemic autoimmune diseases: immunopathogenesis and patient surveillance

This disertation is dedicated to the study of the immune - dependent and molecular genetic mechanisms of the development of immunopathological syndromes in patients with systemic autoimmune diseases, and to the study of their prevalence and management of such patients with assessment of pharmacotherapeutic and pharmacoeconomic feasibility of support therapy. It as improved the model of the formation of persistent Chlamydia infection forms in the experiment and determinated the role of apoptosis in this pathology. Also it was performed the experimental modeling of persistent chlamydial infection in vitro for reactivation infection study in vivo models and described the role of apoptosis in the formation of persistent chlamydia infection forms. It was found that the strain C. trachomatis showed a clear anti apoptotic effect, and isolated aberrant forms of C. trachomatis from the penicillin system were reorganized into typical elementary and reticular bodies with the subsequent development of a manifest infection, depended on the pathogen severity.