Kuznetsov O. fficacy in the correction of immune disorders ASIT and leukocyte dialysate in patients with allergic rhinitis in combination with allergic conjunctivitis

The dissertation is devoted to determining the effectiveness of non-specific and allergen-specific immunotherapy in the correction of immune disorders in patients with seasonal allergic rhinoconjunctivitis (SARC). Based on the obtained results, the means of immunotherapy of patients with SARC were improved and an algorithm of therapy was developed taking into account the severity of the disease and the nature of immune disorders. The main objectives of the study were: to determine the anamnestic data and concomitant pathology that occurs in patients with SARC and forms the background for sensitization of the body; to determine the nature of immune disorders in patients with SARC with moderate and severe course; to establish the cytokine state of patients with SARC with moderate and severe course; to develop an algorithm for immunotherapy of patients with SARC, taking into account the form of the disease and the nature of immune disorders; to investigate the effectiveness of non-specific immunomodulators Imodin and Polyoxidonium in combination with ASIT in the correction of immune disorders in patients with moderate and severe disease; to study the effect of immunotherapy on the clinical course of the disease in persons with severe and moderate SARC.