Zavgorodny M. Biological activity of new quinoline 4-thioderivatives

Guinoline 4-thioderivatives. Establishment of some dependence between biological action and chemical structure with the purpose of purposeful synthesis and search of perspective connections with the expressed biological action. Methods physical (TLC, IR-, UF-spektroskopy, PMR-, mass-spektrometry), biological and biochemical and chemical, and computer prognostication. It has been determined that quinoline 4-thioderivatives in vitro experiments has "trap" properties for superoxidanione and hydroxylradical in aqueous medium and lipid phase It has been shown that the compounds studied are little or nontoxic and have an expressed antioxidant, anti-ischemic and hepatoprotective activity in vivo reducing the indices of oxidizing stress in cerebral hypoxia and chronic hepatic intoxication. The existence of methoxygroup in the 6th position of quinoline cycle has increased anti-ischemic action of the compounds synthesized and ethoxygroup has risen hepatoprotective activity. The sphere of the use is bioorganic chemistry, pharmacology.