Bolsunova O. Immunomodulating abilities of antiviral preparation izatizon

For the first time it has been founded that the antiviral prerararion izatizon possess immunomodulating abilities both in vitro and in vivo systems.The wide spectrum of it's bioligical activities may be explained by the conformationaly-labile structure of the molecule of methisazon - the main active component of izatizon. The main regularity influences on principal lincs of immune system were determined. It has been shawn that izatizon enhanced the amount of lymphocytes that expressed CD 69 anigen on the cell's membrane,stimulates proliferation of T- and B-lymphocytes, rises functional activity of T-lymphocytes, including their ability to produce lymphokines. Izatizon stimulates citotoxic activity of natural killers and macrophages and synthesis of Il-1, it also increases microbicidic activity of serum. Preparation stimulates mainly cell's immunity that espessialy essential for the cells that participate in the process of immunological protection in case of virus infections.