Semenova Y. The effect of acute and repeated cold stress on the cells of immune system in experiment

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0421U103903

Thesis Registration Form

0421U103903.pdf

Applicant for

Semenova Yanina-Mariya Oleksiivna

Specialization

03.00.09 - Імунологія

Date of defense

30-09-2021

Specialized Academic Board

Д 26.001.24

Taras Shevchenko National University of Kyiv

Essay

The experiments were performed on 55 Wistar rats and 125 C57BL mice. Quantitative cellular changes are realized due to proliferation and cell redistribution by cell cycle different phases, as well as by apoptosis and migration, which provides inter-organ redistribution of cells. It was first established that the development of acute cold stress includes bone marrow cell mobilization involving hematopoietic stem cells with CD34hi MNCs-phenotype. It is shown that under repeated stress the accumulation of effects from the sequential induction of several stress reactions does not occur. On the contrary, repetitive stress promotes the development of adaptation. It has been shown for the first time that adaptive anti-stress mechanisms during repetitive stress are enhanced by transplantation of multipotent mesenchymal stromal cells (MSCs) with subsequent suppression of gastric ulceration.

Thesis supervisor

Nikolskyi Ihor Serhiiovych

Official opponents

Garkava Kateryna Grygorivna
Liubych Larysa Dmytrivna

Files

autoreferat-aref.doc

dis.doc

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