Solomennik A. The state of clinicoimmunologic indices and possibility of their correction in patients with viral hepatitis C.

The condition of clinical, biochemical, immunological indices, interferonogenesis and autoimmune processes in 127 patients with chronic hepatitis C of a various activity of process was investigated.It was shown, that the higher activity of chronic hepatitis C is accompanied by the more expressed changes of the indices, characterized the immune state of the organism (all-bound and humoral immunity, nonspecific fastness, IFN system) and on the contrary.The therapeutic efficiency and influence on clinicobiochemical, virological and immunological parameters of combination of a new interferonogenic probiotic subalin and endogenous IFN inductor dipiridamol in the complex therapy of chronic hepatitis C was estimated.It was shown, that alfa-IFN initial content in the blood serum of patients with chronic hepatitis C doesn’t influence on the efficiency of combined therapy of subalin and dipiridamol, but influence on the efficiency of the cycloferon treatment. Presence of antibodies to the liver’s microsomes, native and denaturated DNA in the blood serum of patients with chronic hepatitis C in the titer 1:100 does not influence on the efficiency of the therapy of subalin and dipiridamol or cycloferon.