Motlokhova O. Clinical and immunologic indices and morphological changes of the immune system in bacterial meningitidis and meningoencephalitidis.

Diagnostic criteria for early prognosis of clinical course in patients with bacterial meningitis and meningoencephalitis were established using of clinical, biochemical and immunological examination. The changes of T-cells, humoral and phagocytic immunity (decrease of CD3, CD4, CD8, Ig, complement, phagocytic activity of the neutrophils) were determined in meningococcal and pneumococcal meningitis and meningoencephalitis and were more expressed in pneumococcal infection. There was normalization of the majority of immunogram indices in moderate course and improvement of them in severe course during convalescence. Considerable devastation of lymphoid tissue in the thymus, spleen and lymphatic nodes with insufficiency of the macrophagal link and decrease synthesis of the IL-1 and TNF-a were revealed. Foci of destruction without development of inflammatory reaction in the brain were found in 33,3% cases of pneumococcal meningoencephalitis. DIC-syndrome was associated with decrease by synthesis of the IL-1and TNF-a.