Golovchenko O. Synthesis of novel bioregulators of azole series on the basis of 4,5-difunctionally substituted oxazoles

4,5-difunctionally substituted oxazoles. Research of such transformations of 4,5-difunctionally substituted oxazoles, which would result in new phylums of azoles with biophoric groups - potential bioregulators of different action. Chemical synthesis, IR- and PMR-SPECTROSCOPY, mass spectrometry, X-ray diffraction research. It was shown that all compounds can be easily prepared from readily accessible derivatives of 5-mercapto-, 5-amino- and 5-hydrazino-1,3-oxazoles containing electron-acceptor substituents at the C-4 atom. Of particular interest were found to be complex transformations of 5-hydrazino-1,3-oxazoles into substituted 1,3,4-oxadiazoles and 1,3,4-thiadizoles. Effective immunostimulants increasing phagocitosis in rats almost two times were revealed among the novel azoles.Sphere of use - bioorganic and organic chemistry.