Nesterchuk V. Effectiveness of application of dragees with mixture of household allergens in specific immunotherapy of allergic rhinitises

Dissertational work is devoted to studying of features of clinical and immu-nological status of patients with an all-the-year-round allergic rhinitis (AAR), de-velopment of technique of sublingual specific immunotherapy (SIT), investigation of medical efficiency of sublingual SIT in the nearest period and in one year after treatment in comparison with classical parenteral administration of allergens, and also in combination with immonocorrection or without it. Inspection find out clini-cal features of AAR development in 120 patients of Kyiv and Kyivska oblast for which the diagnosis of AAR was given for the first time. It is shown, that immu-nological status of patients with AAR was characterized by authentic increase in quantity of eosinophils in mucous membrane of nose and in blood, the general IgE and specific IgE-antibodies to household allergens, and condition of a sensitization at patients with AAR was reflected by changes of system and local immunity (de-crease in T-lymphocytes with a phenotypecd2 quantity and decrease of secretional IgA in saliva), that spoke about expediency of carrying out nonspecific immono-correction. The complex technique of treatment of patients with AAR is developed, which includes SIT with use of dragees with mixture of household allergens and preliminary immunocorrection. The following findings were discovered after SIT course: reduction in expres-sion of subjective symptoms at patients, who received SIT sublingually, and also improvement of objective symptoms of disease in greater measure in groups of pa-tients, which received preliminary immunocorrection before SIT course. Effect after realized treatment since one year was kept, it was stable in groups, where immunocorrective therapy had been carried out.