Ryabenko V. The Role of The Thymic Peptides Complex - Thymalin and The Kidney Peptides Complex in Thymocytes Apoptosis Regulation at Physiological Conditions and at The Modulation of Their Intracellular Regulatory Systems Activity.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0404U004463

Thesis Registration Form

0404U004463.pdf

Applicant for

Specialization

  • 14.03.08 - Імунологія та алергологія

04-11-2004

Specialized Academic Board

Д 26.003.02

Essay

It was shown, that thymalin and kidney peptides complex (KPC) act as the physiological regulators of apoptosis thymocytes. It was found that regulation of apoptosis appreciably detected on a proportion of Bcl-2/P53 expression. We showed that the modulation of intracellular regulatory systems activity enhanced thymocytes apoptosis. Thus, thymalin and the KPC act as inhibitors of apoptosis in this conditions. This antiapoptotic influence was specific and caused by Bcl-2 increasing. It was established that the thymic and non lymphoid tissues peptides activate thymocytes apoptosis in NOD mice autoimmune model. The thymic and non lymphoid tissues peptides demonstrated antiapoptotic influence at the model of irradiation-induced thymocytes apoptosis. Thus, peptides preparates are high effective modulators of apoptotic processes of thymocytes.

Read more

Files

dis1.doc

Similar theses

0521U101940

Hayduchok Ihor H.

Immunopathological syndromes in patients with systemic autoimmune diseases: immunopathogenesis and patient surveillance

0421U103550

Aikian Artem Z.

The role of M1 and M2 macrophage phenotypes in the immunopathogenesis of breast adenocarcinoma in the presence or absence of metastases in regional lymph nodes

0521U101728

Svitlana O. Zubchenko

Allergic diseases and chronic Epstein-Barr virus infection: pathogenesis, diagnostic approaches and therapeutic tactics of patient management

0421U102413

Lomikovska Marta Pavlivna

Immunopathogenesis of infectious reactive arthritis in the background of activated obligate infections (Chlamydia trachomatis and Epstein-Barr virus), patient surveillance

0421U102424

Horbal Natalya Myronivna

Features of the immune response in patients with systemic connective tissue diseases and reactivated herpes simplex virus type 1 infection and their management