PETRENRO O. The role of nitric oxide metabolism failure in glaucomatous optic neuropathy development and potentialities of its correction

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0405U000655

Thesis Registration Form

0405U000655.pdf

Applicant for

Specialization

  • 14.01.18 - Очні хвороби

18-02-2005

Specialized Academic Board

К 26.613.05

Essay

Role of nitric oxide in glaucoma pathogenesis had been determined as a result of scientific literature analysis and proper research. Peculiarities of changing of nitric oxide stable metabolite levels in tears and blood plasma in healthy people of different age and sex had been studied. It gave the opportunity for the first time to determine normative indices of nitric oxide in these media of healthy people of different age groups. Principles of NO metabolism change in different POAG stages in patients of different sex had been discovered. Correlation relation between NO stable metabolite levels in tears and aqueous humor in POAG patients had been determined. It gave the opportunity to work out a new non-invasive method of glaucoma development forecasting by oxide potential of an eye. Different ways of medicamental treatment influence on levels of NO biochemical indices and glaucoma stabilization had been studied. It had been discovered hypotensive effect of ascorbic acid both in eye drops and in pillsand also noticeable positive influence of another antioxidant - Cvercetin on ophthalmopressure. Positive influence of the proposed way treatment both on NO stable metabolite levels in tears, blood plasma and on the glaucoma process dynamics had been marked. It offers the challenge to reduce development of glaucomatous neuropathy.

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Files

01-ТитульнаСторінка.doc

03-ПерелікПозначень.doc

04-Вступ.doc

05-Розділ1.doc

06-Розділ2.doc

07-Розділ3.doc

08-Розділ4.doc

09-Рис.4.9.doc

10-Розділ4(Продовження).doc

11-Розділ5.doc

12-Таблиця 5.1.doc

13-Розділ5(Продовження).doc

14-Розділ6.doc

15-таблиці розділу 6.doc

16-Розділ6(Продовження1).doc

17-Розділ6(Продовження2).doc

18-Рис.6.1.doc

19-Рис.6.2.doc

20-Розділ6(Продовження3).doc

21-Розділ7.doc

22-Висновки.doc

23-список використаних джерел.doc

Автореферат(текст-печать).doc

Автореферат(титульна).doc

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