Chuiko O. Synthesis and properties of the functionally substituted gembisphosphonic acids

The dissertation is devoted to investigation of the reaction ability of the aminogroups of the aminobisphosphonic acids and the development methods for the synthesis of the bisphosphonates of new types, bearing heterocyclic or other functional groups for design of possisly biologically active compounds. The (iso)(thio)urea-, guanidyne-, pirimidyne-, thiazolino and thiazolosubstituted bisphosphonic acids and their salts was synthesized, as well as aminohydroxypropane bisphosphonate derivatives. Acidbasic properties of the synthesized compounds presented. It vas found and investigated the unusual pH-dependent E-Z isomerism of the (iso)thiourea substituted bisphosphonates. The methods developed may by applied in the synthesis of the new biologically active bisphosphonates