The work is devoted to the investigaiton of the adherence and immune modulation properties of the Lactobacilli strains isolated from the contents of the gastrointestinal tract of the healthy children 1 - 7 years old and those with dysbacteriosis, as well as strains from the ATCC collection. Lactobacillic strains' adherence investigaiton has shown that all strains isolated from the healthy children were characterised by the moderate and high adherence ability. Their average adherence indices were from 2,24 ± 0,21 to 7,52 ± 0,35 lactobacilli cells per 1 erythrocyte. Strains isolated from the dysbacteriosis were low- or non-adhesive. АТСС strains were high-adhesive. Adherence ability in 63,6 % strains isolated from healthy children did not depend from D-manose. Adherence ability of lactobacilli did not coincide with theirs erythrocyte agglutination ability which was characteristic for 56,1 % strains. D-glucose, DL-galactose, D-mannose, D-fructose, D-xylose, D-raffinose, L-rhamnose, L-arabinose and N-acetyl-D-glucosamine cold both increase and decrease these processes. The investigation of the рН, proteolytic enzymes and lysozim influence on the lactobacilli adherence ability has shown that the most strains were tolerant to these factors' effect. Most changes in adherence indices pepsin caused. Under lysozim influence in 15,2 % strains lower adherence indices were registered than without this enzyme. The investigation of the lactobacilli anti-defensins production ability has shown that no one strain was able to inactivate lysozim. Only 9,1 % of strains were able to inactivate complement but in 1,5 years of preservation they lost this activity. The ability to produce lysozim was shown for 25,7 % of lactobacilli strains. For 24,2 % strains it was low and was from 0,15 ± 0,04 to 3,81 ± 0,11 mkg/ml; in 1,5 % strains it was moderate and 6,38 ± 0,08 mkg/ml. It has been shown that lactobacilli were able to stimulate the non-specific immune responce. After alive L. fermentum ATCC 14931, L. delbrueckiisubsp. bulgaricus432, L. reuteri 19 and L. fermentum 1005 cells intake per os the peritoneal macrophages phagocytic activity was 1,32 - 2,72 times higher, and oxidation activity was 2,27 - 6,45 times higher. These effects were not accompanied by the decrease of the thymus and spleen cell indices, excluding L. delbrueckii subsp. bulgaricus 432 strain which decreaesd the thymus cell index. Under L. plantarum 1005 intake the increase of the murine serum interferon has been shown as well as the increase of macrophages and lymphocytes ability to produce ?- and ?-interferon. It has been shown the 1,64 times decrease of the delayed hypersensitivity reaction intense after per os intake of L. fermentum ATCC 14931 strain. After the performed investigation two groups of strains perspective for the probiotis preparaitons were selected. To the first we referred the strains able to increase the non-specific immune responce activity including phagocytosis intencification ability or lysozim production, and also mostly tolerant to the enzymesinfluence on their adherence. These strains we consider to be perspective for the immune modulation therapy. To the second group we referred the strains with high adherence ability tolerant to the proteolytic enzymes, lysozim and D-manose. These strains are most perspective for the substitution therapy.
