Koliush O. Functional correlation between lipopolysaccharide-binding protein and immune changes in pathogenesis of chronic viral hepatitis C.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0405U001643

Thesis Registration Form

0405U001643.pdf

Applicant for

Specialization

  • 14.01.13 - Інфекційні хвороби

21-04-2005

Specialized Academic Board

Д 26.614.01

State Institution "The L.V. Gromashevsky Institute of epidemiology and infectious diseases of NAMS” of Ukraine"

Essay

The clinical-biochemical, immunological investigation of 151 patients with chronic hepatitis C and 40 patients with B+C were given. The intercorrelation between lipopolysaccharide-binding protein and immune changes in depending on hepatitis activity according to results of liver biopsy has been studied. It was established that chronic hepatitis C is characterized by mild symptomatology with prolonged hyperfermentemia, concomitant syndrome of intestinal flora overgrowth and secondary immunodeficiency. Increased levels of lipopolysaccharide-binding protein correlate with morphological hepatitis activity. Functional correlation between lipopolysaccharide-binding protein and CD16+, CD25+, circulating immune complexes was pathogenically grounded. Expediency of Hylak and Polysorb use in complex therapy of chronic hepatitis C was substantiated.

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Files

SCHEME DII LBP-SCHEME DII LBP.doc

aref.doc

Рисунок 3.11-Рисунок 3.11.doc

ТЕКСТ укр-ТЕКСТ укр.doc

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