Muzychka L. Syntheses of potential bioregulators of pyrimidine series on the basis of stabilized phosphonium ylides

Phosphonium reagents for heterocyclization. Investigation of phosphonium syntheses of new types substituted pyrimidines and their condensed analogues with biophoric groups. Chemical synthesis, IR- and PMR-spectroscopy. It was shown that substituted pyrimidines and their condensed analogues with biophoric groups, which often contain sulphur and phosphorus, can be easily prepared from accessible phosphonium reagents: triphenylphosphoranylidenacetonitrile, 2-benz-imidazolylmethyltriphenylphosphonium chloride and 1-cyano-2-(methylthio)ethenyl-triphenylphosphonium iodide. Of particular interest were phosphonium synthese of new 4-amino-6-mercapto- and 4,6-dimercaptopyrimidine derivatives. Effective antiseptics were revealed among the novel substituted pyrimidines. The sphere of use - bioorganic chemistry, organic chemistry.