Bondarenko S. Synthesis and reaction ability of natural isoflavonoids and their analogues

The series of natural isoflavones, their analogues and isomeric 7-hydroxy- and 6-hydroxy-3-arylcoumarines were synthesized. The reactions with participation of phenolic hydroxy group of 3-arylbenzopyrones, electrophilic and nucleophilic substitution were investigated. The possibility of introduction of amino function in series of 3-arylbenzopyrones were studied. The method of direct amination of 3-arylbenzopyrone ring by substitution of phenolic hydroxy group on arylamino group was offered and borders of the using was determinated at the first. The aminomethylation reactuion in series of natural isoflavones, their analogues was studied. The recyclization conditions of isoflavones with electronodonor groups by interaction of amidines were improved. The conditions of regioselective interaction of isoflavones with hydroxylamine were offered. The structure especiality of natural isoflavones and their analogues by method of NMR 1H was carried out. The anticoagulating and high cholagogue and hypolipidemic activity of some obtained compounds were established by means of biological screening.