Havryliuk V. Subclinical hypothyroidism: peculiarities of lipid metabolism, functional state of cardio-vascular and neuro-muscular systems under conditions of iodine deficiency

Dissertation is dedicated to diagnosis and treatment of subclinical hypothyroidism (SH). Object: diagnosis and treatment of subclinical hypothyroidism (SH). The work is aimed on establishing the frequency, clinico-biochemical, haemodynamic and neuro-muscular peculiarities of SH in patients of the Carpathian region under iodine deficiency and also on determining the efficacy of the therapeutical methods in treatment of this pathology. Methods and apparatus: clinical, instrumental, biochemical, immunoenzymatic; immunoanalyzer "Stat Fax 303 Plus", ultrasonic system "Simens-SL", "Neuroelectro-myograph-2". Theoretical and practical results: the SH frequency among the population living under iodine deficiency, indices dependence of lipide metabolism on TSH level under this pathology, dynamics of disorders in the state of the cardio-vascular and neuro-muscular systems were established and also the combination of medicinal and physiotherapeutical methods for SH treatment was developed and introduced. The new:the SH frequency among population living under iodine deficiency in the Carpathian region was established, data base for long monitoring of thyroid state in persons living in the iodine deficiency area was formed, the therapeutical method for SH treatment in combination with accompanying cardiovascular pathology was worked out and introduced. The level of approach: the results can be used in treating the patients with SH and for training the specialists-endocrinologists. Field of application: endocrinology.