Pobersky D. State of antiendotoxin immunity at the patients with different form of polypoid rhinosinusitis

The dissertation is devoted to the clinical-immunological ground of the differentiated approaches to treatment of patients suffering from polypoid rhinosinusitis with estimation of the state of antiendotoxin immunity, to the purposeful setting of topical steroid (aldecin), bacterial lysate (IRS-19), modern immunomodulative medcine - Manaks, to prognostication of relapses of polypoid process. The results of clinical supervisions, inspection and treatment are represented 112 patients of polypoid rhinosinusitis and in period of remission. Laboratory estimations are the state of antiendotoxine immunity, anti-single-stranded DNA classes М and G, general immunoglobuline of three classes, cytimorphological research of polyps, bacteriological researches of content of noses cavity. Predominance of the reduced level of antiendotoxine antibodies is set, along with the reduced maintenance of general immunoglobuline of the same names classes in the whey of blood, that specifies on the expressed violations in the humoral link of immunity. The changes of level of antiendotoxine antibodies in the whey of blood are unconnected with the cytomorphological features of polyps. The promoted maintenance of anti-single-stranded DNA classes М and G is special at different forms of polypoid rhinosinusitis and in remission, that can be used as prognostic criterion of inflammatory process. On the basis of clinical-immunological description, taking into account the changes of the state of antiendotoxine immunity at the patients of polypoid rhinosinusitis, testimonies to the differentiated setting of topical steroid (aldecin) are grounded, bacterial lysate (IRS-19) and Manaks. Estimation of direct results of treatment and remote supervisions in catamnesis confirms expedience of the differentiated approach to the choice of medicinal preparations.