Zelenyuk M. The biological activity of liposome forms of rhenium(III) com-plex compounds with organic ligands

The object of study: The mechanism of interaction of the liposome forms of rhenium(III) complex compounds with biological objects. The aim of study: To determine the antihaemolytic and antiproliferation properties of rhenium(III) compounds dependence on their structure and methods used for administration into the organism (as solution or incorporated into the liposomes). Methods and equipment: electronic spectroscopy, determination of TBA-active products, thiol-disulfuric coefficient, glutathione, activity of antioxygen protection system enzymes, determination of erythrocytes stability, preparation of liposomes, MTT-test, in vivo models of anemia, spectrophotometer. Theoretical and practical results, newness: The rhenium(III) complex compounds interact with phospholipids by coordination of a phosphate group of lipids to Re26+ fragment. The inclusion of rhenium compounds inside liposome reduces its hydrolytic damage. The antihaemolytic and antiproliferative effects of rhenium(III) compounds become stronger when the lipophily of its ligands increases. It was shown that antihaemolytic efficiency of rhenium compounds depend on the method of compounds’ administration into the organism. Injections of liposome form of rhenium compounds were more effective than injections of compounds’ solutions. The obtained results extend knowledge about the interaction of transition metals complexes with cells membrane. It can be used to increase therapeutic effect of drugs that contain transition metals. The sphere of application: drug technology.