Object of investigation: 3,4,6-Trisubstituted 1,2-di-hydroquinoline-2-ones and heterocyclic systems on their base – azoloquinolines, synthetic methods, properties. Aim of investigation: development of synthetic methods for the novel 1,2-dihydroquinoline-2-one derivatives, as well as, for 1,2,4-triazolo-, tetrazolo[a]-, 1,2,3-triazolo- and imidazo[b]quinolines, study of their structures, che-mical properties and biological action. Methods of investigation and equipment: organic synthesis, thin-layer chromatography, elemental analysis, IR, PMR and UV spectroscopy, mass-spectrometry, X-ray analysis of structure, computing by methods of molecular mechanics and quantum chemistry using programm “Hyper Сhem 6.0” (trial version, http: // www.hyper.com), PASS, and QSAR analyses. Theoretical results and their novelty: For the first time, it was demonstrated that interaction of 5-R-2-chloroacetylaminobenzophenones derivatives with primary and secondary amines, as well as, with potas-sium (sodium) nitrates, cyanides, rodanides had not been limited by nucleophylic substitution of a halogene atom in alyphatic moiety of initial molecule, but resulted in 3,4,6-trisubstituted 1,2-dihydroquinoline-2-ones. It was established that heterocyclization of 2-hydrazino-3-nitroquinolines after effect of nitrous acid proceeded only by one of two alternative pathways: with formation of tetrazolo[1,5-a]quinolines, but not furoxano[3,4-b]-quinolines, what had been stipulated by reaction thermodynamics. It was discovered that the novel reac-tion had been proceed upon the heating of 2-(6-R-3-nitro-4-phenylquinoline-2-yl-sulfanyl)-1-phenylethanones so-lutions in DMF – 2-(6-R-3-nitro-4-phenyl-1H-quinoline-2-ylidene)-1-phenylethanones had been formed as a result of sulfur atom extrusion and substituent rear-rangement. Practical results and their novelty: сonveni-ent methods of obtaining of not previously described 3,4,6-trisubstituted 1,2-dihydroquinoline-2-ones, as well as, their 2-chloro-, 2-mercapto-, 2-hydrazino- and 2,3-diaminoderivatives and quinolines with annelated azole cores on their base, were developed. It was developed the original approach to 2-(6-R-3-nitro-4-phenyl-1H-quinoline-2-ylidene)-1-phenylethanones synthesis. It was shown that 3-nitro-2-chloroquinoline and 2,3-diamino-quinoline derivatives had been convenient synthones for obtaining of 1,2,3-triazolo[4,5-b]- and imidazo[4,5-b]-quinolines. Among the denovo synthesized quinoline derivatives were identified the substances with a high anticonvulsive and antibacterial activity, for the studied compounds, structure-activity relationship was revealed. Resulting from PASS and QSAR analyses, potential fields for the use of obtained compounds were defined for the search for novel physiologically active substances in this series. Subject and the degree of introduction: publications, reports at scientific conferences, application of the work in scientific-pedagogical practice in High-schools and Investigation Institutes of Ukraine. Efficiency of introduction consists in development of synthetic methods of 3,4,6-trisubstituted 1,2-dihydroqui-noline-2-ones and quinolines with annelated azole cores on their base, as well as, in estimation of prospectivity of search for novel anticonvulsive and antibacterial agents in their series. Sphere of use: chemistry, biology, medicine.
