Shumilo I. Uterine sarcoma: peculiarities of clinical morphological diagnosis and tactics of treatment.

The object - the patients with uterine sarcoma. The purpose - to develop clinicomorphologic criteria of diagnostics and tactics of treatment for increasing the efficiency of treatment of the patients with uterine sarcoma. The methods - clinicals methods, morphologic methods including histochemical, immunohistochemical and morphometric methods, statistical methods. The results - the method of treatment of the patients with uterine sarcoma after non-radical operations is developed and introduced into practice of public health services. It is proved that colpocervixectomy in patients with uterine sarcoma after non-radical operations improves 5-year survival of patients in average at 20% in comparison with radiotherapy or chemotherapy. For the first time the theoretical substantiation of an adequacy and expedience of colpocervixectomy in patients with uterine sarcoma after non-radical operations on the basis of results of clinic morphological investigation is given. Clinical and morphological substantiation of an expedience and necessity of colpocervixectomy in patients with uterine sarcoma of different histogenesis and the degree of differentiation after non-radical operations are described. It is established, that the factors influencing on prognosis at uterine sarcoma are advanced age, non - radical operative treatment, low degree of tumours differentiation, tumours invasion into uterine cervix, tumours invasion of blood vessels. It is shown, that risk factors of uterine sarcomas development are primary and secondary infertility, uterine myoma, proliferative processes of endometrium. It is introduced in oncology clinics of Donetsk, Gorlovka and Yenakievo. The area - medicine (oncology).