Lysenko S. Тhe Brain dislocations at patients with gliomas of supratentorial lo-calization and their importance during surgical treatment.

The thesis is dedicated to improvement of results of surgical treatment of patients with gliomas of supratentorial localization. Optimization of diagnostics, prophylaxis and treatment methods was carried out on the basis of prediction of postoperative dislocation complications.Dislocation complication rate during surgical treatment of patients with gliomas of cerebral hemispheres has been determined, and their role in the structure of postoperative lethality has been defined.Prognostic value of separate factors and their combinations that affect the risk of development of postoperative dislocation complications at the pre-, intra-, and postoperative stages has been determined. Based on the clinical-and-statistic prediction, we have elaborated and introduced in neuro-oncological practice the clinicodiagnostic standards and algorithms of prophylactic and therapeutic measures with patients who have gliomas of supratentorial localization; those measures are aimed at minimization of risk of occurrence of dislocation complications caused by development of cerebral edema, hemo- and liquor-circulation disorders. The method of prediction of postoperative dislocation complications that allows to determine the risk of their occurrence, define indications and contraindications to surgical treatment of patients with gliomas of supratentorial localization has been suggested.Introduction of diagnostic and preventive algorithms, therapeutic standards, taking into account the data of clinical-and-statistic analysis and prediction that were carried out, allowed to minimize the risk of development of postoperative hemo-, liquorcirculation complications and dislocation phenomena related to them, which has improved the results of patients treatment and allowed to reduce the rates of postsurgical lethality for the last five years - from the year 2000 to 2004 (2,1 %) compared to the period from the year 1995 to 1999 (4,17 %) accordingly by a factor of 2,17 (р = 0,0006).