Dubey N. Peculiarities ofvendocrine regulation of caltium metabolism in newborn from mother with iron deficiency anemia.

Object of the research: Endocrine system and calcium me-tabolism in early neonates from mothers with IDA. Purpose of the research: To improve the methods for correction of adaptation period in children of early neonate age born from the mothers with iron-deficiency anemia based on the study of neuroendocrine regulation of calcium metabolism and breast milk hormones. Methods of the research: Clinical, laboratory (hematological, biochemical, radioimmune) and instrumental studies. Practical significance of the obtained findings: The possibility to use hormonal parameters of the blood serum in infants born from the mothers with IDA and breast milk during lactation for objective assessment of calcium metabolism in neonates. The parameters of endocrine regulation of calcium metabolism in mature infants in an early neonatal period are informative criteria of maturity and satisfactory course of adaptation period. A risk group of adaptation failure in early neonatal period includes immature newborns, in particular, born at the age <28 weeks of gestation. Taking into account that the breast milk contains high concentrations of a number of calcium-regulating hormones and they take part in calcium metabolism in the gastrointestinal tract, the newborns should be given the breast milk in the delivery room. The new data about the hormonal state of the breast milk can be used for creation of biologically active additives to the milk mixtures. Novelty: For the first time, great clinical material was used to study the characteristics of neuroendocrine regulation of calcium metabolism in children of early neonatal period born from the mothers with IDA, which participates in adaptation processes. It was established that in calcium-regulating hormonal profile of newborns from mothers with IDA, new qualitative and qualitative changes take place. The obtained data expand the range of modern ideas about the disturbances of calcium metabolism in these children and open a new perspective in correction of these shifts. Correlation of neuroendocrine regulation of calcium metabolism and the degree of the newborn maturity. For the first time, the role of breast milk hormones Degree of introduction: The findings of the research were introduced to the work of outpatient department of Institute for Blood Pathology and Transfusion medicine (Lviv), Lviv Regional Children's Hospital "OHMADET", Regional Children's Specialized Clinical hospital, City Children's Clinical Hospital and Hospital No. 5, which is proved by acts of intro-duction. Sphere of application: Medicine, pediatrics.