Onyshchenko O. Assessment of left ventricular structure and function, hemodynamic parameters in patients with chronic mitral regurgitation

Subject of research: patients with chronic mitral regurgitation. Aim: the improvement of diagnostics quality of mitral regurgitation and assessment of functional status of left ventricle and prediction of unfavorable outcome of chronic mitral regurgitation. Methods: clinical, ultrasonographical, electrophysiological, statistical. Novelty: comparative analysis of semiquantitative and quantitative methods of mitral regurgitation assessment using transthoracic and transesophageal echocardiography has been completed; prognostic concernment of parameters has been demonstrated; for the first time use of tissue Doppler imaging in diagnostic of latent left ventricular systolic dysfunction has been shown; for the first time based on tissue Doppler imaging and M-mode color Doppler approaches to assessment of diastolic function in patients with chronic mitral regurgitation have been developed; the progression character of mitral regurgitation and left ventricular structure and function abnormalities in prospective study has been assessed. Results: criteria's of differentiate use of semiquantitative and quantitative echocardiographic methods of mitral regurgitation degree assessment have been developed; echocardiographic markers of latent left ventricular systolic dysfunction in asymptomatic patients with chronic mitral regurgitation have been determined; usefulness diagnostic of type of left ventricular diastolic dysfunction by tissue Doppler imaging and M-mode color Doppler has been proved; prognostic criteria's of unfavorable outcome of chronic mitral regurgitation have been developed. It has been introduce in practice of Donetsk, Simferopol and Zaporozhye hospitals; sphere of using: medical-diagnostic process of rheumatology, cardiology departments and diagnostic departments.