Merkulova K. Automatized system of definition cells viability (by the exemple of cultivated fibroblasts)

Object of research: the processing of designing and component development of math software for automated systems of experimental results processing and decision-making. The purpose of research: development of the automatized system of definition of viability of cells by the example of cultivated fibroblasts, providing efficiency increase and accuracy of decision-making on fibroblasts viability due to the use of methods, algorithms and the software of processing the information with application of modern computer technical equipment. The methods of research used in work, are based on application of substantive provisions of probability theory and mathematical statistics, the modular approach, the theory of matrixes, synergetrics, the system approach, and also methods of digital processing of images and methods of mathematical modelling are applied. Theoretical and practical results: the automated system of definition of cells viability is developed. Novelty: for the first time it is offered the method of estimation of cells viability fot the automatized system; it has received the further development a method of classification vectors construction of fibroblasts monolayers images; for the first time the method of classification of fibroblasts monolayers images is offered on the basis of simultaneous use of Mahalonobis and Euklid distances; for the first time the structure of the automated system of definition of cells viability and support of decision-making about the condition of cultivated fibroblasts is developed. A degree of introduction: the result are introduced at Institute of urgent and regenerative surgery named after V.K.Gusak, scientifice research institute of medical problems of family, in some research work done at Donetsk national technical university and are used in educational process provided on the faculty "Automated control systems" in Donetsk national technical university. Area of use: medicine.