Golyarnik N. The role of opiate peptides in the modulation of immune response in patients with discirculatory encephalopathy at the late period after radiation exposure

Complex clinic-immunological study was performed of 153 Chornobyl accident consequences cleanup workers wicth cerebral vascular pathology, exposed at the range of doses of 0,25-3,8 Sv at the late period after radiation exposure (13-18 years). Data were obtained on the preservation of stable T-lymphocyte subset structure and function changes. Role of endorphins was demonstrated in neuro-humoral regulation and modification of presentation of surface lymphocyte antigens and development of immunodeficiency. Reverse dose-effect dependencies were shown for CD3+ and CD4+ cell counts. In patients exposed below 0,9 Sv elevated expression of activation antigens wos shown including CD25 and HLA-DR. The immunomodulatory characteristics of endorphins are described. The specific nature of spontaneous and mitogen-induced activation of immune cells is explored, the comparative research of the endorphins influence on the surface phenotype and processes of mitogen-induced activation. Differences were shown in the lymphocyte sensitivity to A- and B-endorphins. The presence of the radiation effects in opiate regulation of immune response in the late period after exposure of 1 Sv and more is described and the pathogenetic role of the changes in the sensitivity of lymphocytes to endorphins in the development and manifestation of immunodeficiency during cerebral vascular pathology is explored.