Sokolenko T. Synthesis and properties of azoles with а,а-difluoromethylene fragment directly bonded to the nitrogen heteroatom

Dissertation dials with synthesis and properties of five membered nitrogen-containing heterocycles with fluoroalkyl groups directly bonded to the nitrogen atoms. New and improved methods of synthesis of N-fluoroalkylated azoles were developed. Imidazole and pyrazole with N-trifluoromethyl group were prepared. Properties of azoles with N-fluoroalkylated groups were studied on N-1,1,2,2-thethrafluoroethyl derivatives of pyrrole, imidazole and pyrazole, as model substrate. It was determinate that N-fluoroalkyl groups are stable in various chemical transformations of heterocycles nucleus i.e. litiations. New derivatives of dihydropyridine were prepared. New type stable ambient temperature ionic liquids synthesized.