Bezrukova T. The prognostic risk criteria of wheezing recurrences in young children

The thesis is dedicated to the prognosis of the recurrences of bronchial obstruction in young children with wheeze during acute respiratory illnesses after the in-patient hospital treatment, establishing of risk factors for transient early and persistent wheezing phenotypes in children using longitudinal catamnestic observation. It was established that 55,4% of the patients had no wheezing in the future, in 15,9% of observations wheezing acquired transient pattern and ceased at pre-school age, in 19,7% of sick children recurrent bronchial obstruction persisted until 15 years of age and in 9% of the patients it continued at older age and during the adulthood. The most important risk factors of recurrent and persistent wheezing were onset of wheeze after two years of age, urban residence, frequency of the previous wheezing illness more than 3, positive individual allergic anamnesis, sharply positive skin-test reactivity to basic groups of non-bacterial allergens and stable blood eosinophilia. It was indicated that individual prognosis of wheezing pattern in young children must be performed from the position of complex assessment of risk factors in their interaction using the methods of mathematical modelling.