Markeeva N. Beta-defensin-2 in malignant transformed epithelial cells

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0406U001746

Applicant for

Specialization

  • 14.01.07 - Онкологія

19-04-2006

Specialized Academic Board

Д 25.155.01

Essay

The dissertation is aimed on the study of biological role of recombinant human beta-defensin-2, particularly its influence on viability and proliferation of malignant transformed epithelial cells in vitro, and the patterns of hBD-2 expression on the level of mRNA and protein in gastric and cervical cancers. Recombinant beta- defensin-2 was generated, the scheme of its purification was developed, monoclonal anti-hBD-2-antibodies were received. The relation between the production of beta-dwas demonstratedefensin-2 and the degree of transformation of cervical epithelium

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