Momot V. Characteristic of the functional state of liver monooxygenase system under N-nitrosodiethylamine-induced hepatocarcinogenesis

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0406U001897

Thesis Registration Form

0406U001897.pdf

Applicant for

Specialization

  • 14.01.07 - Онкологія

12-04-2006

Specialized Academic Board

Д 26.155.01

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine

Essay

3. 3. The dissertation presents the results of studying the functional activity of monooxygenase complex in liver under N-nitrosodiethylamine -induced hepatocarcinogenesis in rats. The changes in content of total and reduced cytochrome P-450 and cytochrome b5 as well as in activity of NADH cytochrome b5 - reductase, para-aniline hydroxylase and benzphetamine dimethylase were found to have a phase character and depend on carcinogenesis stage. Significant decrease in content of constitution isoforms of cytochrome P-450 and expression of IA1 were observed at the initiation –promotion as well as progression stages of hepatocarcinogenesis. It was shown that retinol acetate and ascorbic acid did not posses with defense action but shortened the latent period of tumor output under condition of N- nitrosodiethylamine-caused disturbance in liver functions.

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Files

Disser_1_5.doc

Glava 3_1-3_new.doc

Glava_3_4_new.doc

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Introduction.doc

Matherial_Methods.doc

Obzor_lit.doc

REFERAT_2.doc

References.doc

zakluchenie.doc

Выводы.doc

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