Yakovleva I. Peculiarities of gastroduodenal pathology in adolescents with systemic connective tissue dysplasia

The principal issues of the thesis contain the data on improving prophylaxis and treatment of chronic gastroduodenal pathology in adolescents with systemic connective tissue dysplasia (SCTD) on the basis of determining clinical, morphological and immunologic peculiarities of said pathology. The role of SCTD in the development of gastroduodenal pathology in puberty has been outlined. It has been established that a main factor in gastroduodenal pathology formation in patients with SCTD is the reflux of the aggressive content against the background of genetically dependent insufficiency of interstitial collagen in lamina propre of gastral and duodenal mucosae. It has been revealed that clinical manifestations of gastroduodenal pathology in adolescents with SCTD are formed against the background of an increase in functional activity of monocytic and phagocytic link cells accompanied by a decrease in their number, the T-system immunity depression and that of the B- system activation with hyperproduction ofIgA, antibodies to collagen and elastin, and of secretory IgA. Compensatory rise in IgA secretory level is aimed at normalizing the immune system parameters and at slowing down the autoimmune processes in connective tissue. It has been established that the refluxes contribute to lowering the local immunity. The work provides grounds for employing in adolescents with SCTD rehabilitation measures, connected with prevention of reflux-gastritis progression and with correction of immunologic homeostasis with obligatory inclusion to the routine treatment complex of prokinetic drugs, metabolites-energizers and stimulation of synthesis of collagen.