Stepanyuk A. Mechanisms underlying decay of prolonged GABAergic IPSC in hippocampal cultured neurons

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0406U002503

Applicant for

Specialization

  • 03.00.02 - Біофізика

11-04-2006

Specialized Academic Board

Д 26.198.01

Bogomoletz Institute of Physiology National of science of Ukraine

Essay

In this study, we found that in a considerable part of the cultured hippocampal neurons eIPSC decayed more slowly than mIPSC did. Our results indicate that asynchronous release of synaptic vesicles cannot explain the prolonged decay of the GABA-ergic IPSC. We suggest that some interaction between the quanta at the pre- and/or post-synaptic level should result in a slower decay of the eIPSC in comparison with that of mIPSC.

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