Belyuga O. Synthesis of novel bioregulators - derivatives of nitrogencontaining heterocycles on the basis of amidophenacylic reagents

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0406U002527

Applicant for

Specialization

  • 02.00.10 - Біоорганічна хімія

09-06-2006

Specialized Academic Board

Д 26.220.01

V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine

Essay

Amidophenacylic reagents. The research of heterocyclizations on the basis of amidophenacylic reagents. Chemical synthesis, IR- and PMR-spectroscopy, mass spectrometry, X-ray diffraction research. It was researched of heterocyclizations based on amidophenacylic reagents which are available for the preparative synthesis of a number of functional derivatives of oxazoles, thiazoles, imidazoles, imidazo[1,2-a]azines and imidazo[2,1 b]azoles. All of them are potential bioregulators, and some of them are useful as an effective immunostimulants which increase proliferation of thymocites in rats on 60-70% and fagocitosis in 1.5 times. Sphere of use - bioorganic and organic chemistry.

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