Rodik R. Functionalization of calixarenes with nitrogen containing pharmacophoric groups

The dissertation is devoted to functionalization of calixarenes with nitrogen containing pharmacophoric groups (amide, carbamide, amidine, imine, ammonium, tetrazol, quinazolinone, aminophosphonic) and to investigation of their spatial structure. The method of calixareneimidoylchlorides's synthesis was developed. These compounds were used for synthesis of calixarenes modified with heterocyclic fragments. It was found that calixarenes obtained readily form complexes with metal cations and include various organic molecules in the cavity due to intermolecular hydrogen bonds and other non-valent interactions. Metallocomplexes of iminocalix[4]arenes and calix[4]arenetetratetrazole with PdCl2 form cage-like structures or nanoclusters in crystalline state. It was shown that calixarenes possessing sulfonylamidine, amide and aminophosphonic groups effectively inhibit calcium and sodium pumps of smooth muscle cells. It was found that diamide of diaminocalixarene and p-chlorobenzoic avid can bind central benzodiazepine receptors of central nervous system of mammalian.