Object of the research:research object are women of different age with an estrogenic deficit.Goal of the research: The purpose is to perfect diagnostics, prophylaxis and treatment of structurally-functional violations of bone fabric with women having an estrogenic deficit in different age peri-ods.Methods of research: Research methods are general clinical, neuroorthopedic| and anthropometric inspection, questionnaire (questionnaire of World Health Organization, WHO, Mac-Gilovksiy| question-naire combined with a visual-analog scale, questionnaire to expose the peculiarities of actual nourishment), immunological (determination| of the level of interleukin-6), biochemical (determination of the level of pirilinks), dioxypyrydinoline), osteocalcin), hormonal (determination of the level of estradiol, progesterone, LG, FSG, prolactin|, testosterone) researches, study of physical and sexual development of girls, roentgeno-logic (X-ray morphometry of spine, X-ray density sensitome-try of autopodium with the use of "Osteologist"), ultrasonic density sensitometry with the help of "Ahilles+" equipment, gynaecological inspection, statistical methods. Scientific novelty: comparative estimation of features of the structurally-functional state of bone fabric, X-ray morphometry, X-ray density sensitometry and anthropometric indexes is for the first time conducted at an estrogenic deficit with women in different age periods.The features of forming of peak of bone mass are defined among girls and teenagers depending on anthropometric de-scriptions, level of sexual development, peculiarities of forming of menstrual function and actual nourishment. It is shown that the risk of development of metabolic and structurally-functional violations of bone fabric among women of different age is related to the estrogenic deficit. The role of sexual hor-mones, cytokines| (interleukin-6) is set in forming of violations of the structurally-functional state of bone fabric in different age periods; the role of actual nourishment is defined in devel-opment of structurally-functional violations of bone fabric in the adolescent period of girls. Efficiency of the medicinal pro-grams is studied in the prophylaxis of violations of the struc-turally-functional state of bone fabric in the case of an estro-genic deficit with the women of different age.The practical importance:The relation is first set between anthropometric indexes (height, mass, circumference of thorax, sizes of pelvis) and level of sexual development. It is certain that girls with pathol-ogy of becoming of menstrual cycle and slow pubescence make the group of risk on development of osteoporosis in the future. The most essential period for forming of peak of bone mass is a transition from pre-adolescent into the adolescent stage of sexual development (10-12 years). The deficit of albumens, calcium and D-vitamin in the actual ration of of girls is an additional factor of risk on development of violations of forming of peak of bone mass, development of osteopanic syndrome. The features of X-ray density sensitometry, X-ray morphometry and density sensitometry indexes of the structur-ally-functional state of bone fabric are studied with women with a estrogenic deficit.The system of screening of violations of the structurally-functional state of bone fabric is improved; X-ray morphome-try, X-ray density sensitometry , ultrasonic density sensitome-try is an adequate method for estimation this contingent. It is proved that X-ray density sensitometry index (integral кортикальный index of autopodium) and ultrasonic index (index of density) can be used for estimation of the structur-ally-functional state of bone fabric, dynamic supervision after it at prophylaxis and treatment among women with an estrogenic deficit. Biochemical markers of remodeling of bone fabric (dioxypyridinoline, osteocalcine) are the most sensitive at the changes of metabolism of bone fabric, at treatment of structur-ally-functional violations of bone fabric. Medical complexes are offered with the use of preparation of calcium, D-vitamin and microelements (calcemine) and preparations of replacing hor-monal therapy, which are instrumental in normalization of violations of the structurally-functional state of bone fabric in different periods of female development.Results of conducted researches are applied during clinical practice in the Institute of gerontology of Academy of Medical Science of Ukraine (Kiev), Institute| of traumatology and orthopedics of АМS of Ukraine (Kiev), Lugansk regional clinical and child's hospital (Lugansk), the Ukrainian, scientific and medical centers of problems of osteoporosis, the depart-ment of traumatology and orthopedics of the National.Traumatology and orthopedics.
