Zakrevs'kyj A. Diagnostics and prognostication of the current of the destruction hypoxic defeats of central nervous system at full-term newborns

The dissertation contains theoretical generalization and new solution of the actual scientific task - the improvement for the early diagnostics of the brain (injury) destructive defeats and prognostication of the current of the perinatal hypoxic defeats of CNS at full-term newborns in an acute period by the complex analysis of the clinical and neurological symptoms, neurosonographic and electroencephalographic pattern subject to the levels of the cyclic nucleotide exchange (cAMP, cGMP) and purines (xanthine, hypoxanthine) covered with blood and liquor. The research result of 125 full-term newborns has been analyzed. Where 102 newborns had hypoxic defeats of CNS. 1st group: there are 24 (19,2%) patients had destructive damages of the brain and the unfavorable outcome of the disease; 2nd group: there are 30 children had destructive damages of the brain and favorable outcome of the disease; 3rd group: there are 48 (38,4%) newborns who had mainly functional damages of the CNS. 23 healthy full-term newbornsmade up a control group. Early diagnosis of brain destruction and prognostication of the hypoxic defeats of CNS of newborns are possible with using the determination of the cyclic nucleotides (cAMF, cGMF) content covered with blood and liquor full-term newborns having hypoxic defeats of CNS in an early stage. It was created and tested a new computer program.